产品名称：SE 175
英文名称：SE 175
英文别名：2-[[4-[(nitrooxy)methyl]benzoyl]thio]-benzoic acid, methyl ester
运输条件：超低温冰袋运输
SE 175是与硝酸甘油相同类别的有机硝酸盐化合物。在硝酸盐基团还原转化为一氧化氮后的生理条件下，这些硝酸盐化合物可作为NO供体。为了促进该还原过程并加速NO的释放，开发了硝氧基酰化的硫代水杨酸酯，例如SE 175。SE 175在缓冲液或盐溶液中稳定。在大鼠的研究中，已显示出可刺激内皮可溶性鸟苷酸环化酶（sGC）并诱导主动脉血管舒张（EC | 50 | = 20 µM）。SE 175的效价介于硝酸甘油和硝酸异山梨酯的效价之间。
SE 175 is an organic nitrate compound of the same general class as nitroglycerin. These nitrate compounds can act as NO-donors under physiological conditions following reductive transformation of the nitrate group to nitric oxide. The nitroxyacylated thiosalicylates, such as SE 175, were developed in an effort to facilitate this reductive process and accelerate the release of NO. SE 175 is stable in buffer or saline solution. In studies with rats, it has been shown to stimulate endothelial soluble guanylate cyclase (sGC) and induce aortic vasorelaxation (EC|50|= 20 μM). The potency of SE 175 lies between that of nitroglycerine and isosorbide dinitrate.
CAS编号：258278-64-7
储存温度-20°C
储存分子量：347.34Smiles
COC(=O)C1=CC=CC=C1SC(=O)C2=CC=C(C=C2)CO[N+](=O)[O-]
货号：Delta-10521574
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