CAS:2764-03-6|亚油酰甘氨酸
-
产品别名:
Linoleoyl glycine
-
CAS 号:
2764-03-6
-
分 子 量:
337.5
-
分 子 式:
C₂₀H₃₅NO₃
-
产品纯度:
≥95%
-
产品规格:
100mg,500mg(可根据需求定制)
-
运输条件:
顺丰速运包邮
-
产品说明:
此产品仅用于科研,不能用于人体治疗、药物开发、和其他商业用途。
-
更新时间:
2023-03-01 10:45:50
产品名称:亚油酰甘氨酸
英文名称:Linoleoyl glycine
英文别名:Glycine linoleamide
运输条件:超低温冰袋运输
亚油酰甘氨酸是亚油酰甘氨酸亚油酰乙醇酰胺的内源同系物。花生四烯酸甘氨酸是在哺乳动物皮肤,脊髓和大脑中产生的花生四烯酸和甘氨酸的结合物,它是anandamide(AEA)的结构对应物,据报道在整个动物实验中具有镇痛作用。它对中央大麻素(CB1)受体的亲和力较弱,对G蛋白偶联受体GPR-18的亲和力高,并且受脂肪酸酰胺水解酶(FAAH)活性的代谢调控。亚油酰基甘氨酸抑制含有FAAH的N18TG2细胞膜(IC | 50 |〜25 µM)中AEA的水解,其效力低于花生四烯酸甘氨酸(IC | 50 | = 7 µM
Linoleoyl glycine is an endogenous homolog of linoleoyl ethanolamide, an arachidonyl glycine. Arachidonyl glycine, the conjugate of arachidonic acid and glycine produced in mammalian skin, spinal cord and brain, is a structural counterpart of anandamide (AEA) that is reported to have analgesic activities in whole animal experiments. It has poor affinity for the central cannabinoid (CB1) receptor, high-affinity for the G protein-coupled receptor GPR-18, and is metabolically regulated by fatty acid amide hydrolase (FAAH) activity. Linoleoyl glycine inhibits the hydrolysis of AEA in FAAH-containing N18TG2 cell membranes (IC|50|~ 25 μM), which is less potent than that of arachidonyl glycine (IC|50|= 7 μM). The biological significance of linoleoyl glycine has not yet been determined.
CAS编号:2764-03-6
溶解性:Soluble in DMSO, dimethyl formamide and ethanol.
储存温度-20°C储存
分子量:337.5
分子式:C₂₀H₃₅NO₃
Smiles:CCCCC/C=C\\\\C/C=C\\\\CCCCCCCC(=O)NCC(=O)O
PubChem CID:6433346
德尔塔热门产品推荐:
DSPE-PEG-COOH,二硬脂酰磷脂酰乙醇胺-聚乙二醇-羧基
DSPE-PEG-Mal、二硬脂酰磷脂酰乙醇胺-聚乙二醇-马来酰亚胺
DSPE-PEG-cRGD,磷脂-聚乙二醇-靶向穿膜肽cRGD
羧基化四氧化三铁纳米粒子,DMSA Coated Fe3O4 Nanoparticles
DMG-PEG2000,1,2-二肉豆蔻酰-rac-甘油-3-甲氧基聚乙二醇
在线留言
您好,欢迎您访问德尔塔生物官方网站,请留下您的需求,我们会派专业人员为您提供最优的个性化精准产品方案。 并且将严格保密您提交的信息,请放心填写,我们将在收到留言后24小时内向您回复~
产品推荐
-
CAS:73246-45-4|S2氯丙酸甲酯
-
CAS:18138-04-0|23二乙基5甲基吡嗪
-
CAS:6702-50-7|Methyl 3-hydroxy-4-methoxybenzoate
-
CAS:2632-10-2|2溴34二氯苯乙酮
-
CAS:186259-63-2|2,7-Dibromo-9,9-diphenyl-fluororene
-
CAS:12246-51-4|Chlorobis(cyclooctene)iridium(I)dimer
-
CAS:641-74-7|Isomannide
-
CAS:90381-07-0|5-Chloro-2-(trifluoromethyl)benzaldehyde