产品名称：6α-前列腺素I1
英文名称：6α-Prostaglandin I1
英文别名：6α-PGI1 5,6α-dihydro PGI2
运输条件：超低温冰袋运输
6α-前列腺素I1（6α-PGI1）是稳定的前列腺素I2（PGI2）类似物，可抵抗水溶液中的水解。6α-PGI1以浓度依赖的方式促进人甲状腺切片和细胞中环AMP的积累。然而，在引起反应中，其效力比β-异构体低约10倍，而效力比PGI2低约100倍。6α-PGI1抑制ADP诱导的血小板凝集的IC 50为350 ng / ml，比PGI2（0.4 ng / ml）高出近900倍。
6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. 6α-PGI1 promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration dependent manner. However, it is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting the response. 6α-PGI1 exhibits an IC|50|of 350 ng/ml for inhibition of ADP-induced platelet aggregation, which is nearly 900-fold higher than that observed for PGI2 (0.4 ng/ml).
CAS编号：62777-90-6溶解性：Soluble in water (>0.08 mg/ml at 25° C), DMSO (~5 mg/ml), DMF (~10 mg/ml), ethanol (~20 mg/ml), and PBS pH7.2 (~0.08 mg/ml).

储存温度-20°C
储存分子量：354.5
分子式：C₂₀H₃₄O₅Smiles
CCCCC[C@@H](/C=C/[C@@H]1[C@H]2C[C@H](O[C@H]2C[C@H]1O)CCCCC(=O)O)O
IC50
ADP-induced platelet aggregation: IC₅₀= 350 ng/ml

货号：Delta-35024150

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