产品名称：N-棕榈酰-D-鞘氨醇
英文名称：N-Palmitoyl-D-sphingosine
别名：(2S,3R,4E)-2-(棕榈酰氨基)-4-十八碳烯-1,3-二醇, N-[(1S,2R,3E)-2-羟基-1-（羟甲基）-3-庚烯-1-基]十六烷酰胺, N-棕榈酰-D-赤型-鞘氨醇, N-棕榈酰-D-鞘氨醇, C16-神经酰胺, C16神经酰胺(d18:1/16:0)
英文别名：C16 Ceramide (d18:1/16:0)； N-palmitoyl-D-erythro-sphingosine, powder； Cer(d18:1/16:0)；D-erythro-N-Palmitoylsphingosine；N-Hexadecanoyl-D-erythro-sphingosine
规格或纯度：>99%
运输条件：超低温冰袋运输
生化机理
C16 Ceramide levels are elevated in chronic alcohol-related liver disease (ALD). In general, ceramide inhibits mitochondrial function and insulin signaling. They are essential component of cell membrane and are involved in lipid raft formation. C16 ceramide based analog (C2-C16 CCPS) is potential anticancer agent used in chemotherapy. The levels of C16 ceramide and its ratio with other ceramides is regarded as a biomarker in predicting coronary artery disease (CAD). It interacts with the DNA-binding domain of tumor suppressor protein p53 and activates p53.Endogenous ceramide. Various pharmacological activities. Activates protein kinase and induces phosphorylation of EGFR. Activates NF-kappaB and induces apoptosis. Active in vivo and in vitro .
Ceramide comprise sphingosine and fatty acid and belongs to the sphingolipids family• as an internal standard in the chromatography with negative ion electrospray ionization coupled to tandem mass spectrometry for myocardial ceramide quantification• as an internal standard for the ceramide quantification from rat samples using liquid chromatography-mass spectrometry• to test its effect on mitochondrial stress response in worms
CAS编号：24696-26-2
敏感性：吸湿的；对空气敏感
熔点：98 - 99°C
溶解性：Soluble in DMF at 0.15mg/ml
储存温度-20°C储存,充氩
MDL号：MFCD00871748
分子量：537.901
分子式：C34H67NO3
备注：如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。卖完停产，不再备货
PubChem CID：5353456
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