生物活性：5-Aminosalicylic acid-13C6 is the 13C labeled 5-Aminosalicylic Acid[1]. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[2][3][4].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
5-Aminosalicylic acid-13C6 相关抗体:
BNSP Antibody
FACL4 Antibody
BrdU Antibody (YA578)
NF-KB p65 Antibody
Phospho-NF-KB p65 (Ser536) Antibody
GAPDH Antibody
Phospho-NF-κB p65 (Ser529) Antibody
Glucose 6 Phosphate Dehydrogenase Antibody
PPAR alpha Antibody
METTL3 Antibody
NF-KB p65 Antibody (YA267)
PPAR gamma Antibody
TSG101 Antibody
Alkaline Phosphatase Antibody
Calnexin Antibody (YA573)
Lamin A/C Antibody
Lamin B1 Antibody
LAMP1 Antibody
LAMP2 Antibody (YA713)
LAMP2a Antibody
NF-KB p105/p50 Antibody
NQO1 Antibody (YA697)
NQO1 Antibody (YA261)
OPA1 Antibody
RBM3 Antibody
RelB Antibody
Ret Antibody
Retinoic Acid Receptor alpha Antibody
SOD2 Antibody (YA071)
SOX1 Antibody
分子量：159.09
Formula：C13C6H7NO3
CAS 号：1189709-96-3
非标记 CAS：89-57-6
中文名称：美沙拉嗪-13C6
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (529 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
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[2]. Dammann K, et al. PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2349-60.
 [Content Brief]
[3]. Fang HM, et al. 5-aminosalicylic acid in combination with Nimesulide inhibits proliferation of colon carcinoma cells in vitro. World J Gastroenterol. 2007 May 2813(20):2872-7.
 [Content Brief]
[4]. Rousseaux C, et al. The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ. Carcinogenesis. 2013 Nov34(11):2580-6.
 [Content Brief]