Name:Sorafenib (BAY 43-9006)
Synonyms:NSC-724772,BAY 43-9006
CAS Number:284461-73-0
Formula:C21H16ClF3N4O3
M.w.:464.82
DMSO (mg/mL)Max Solubility:63
DMSO (mM)Max Solubility:135.54
Form:Free Base
SMILES:CNC(=O)C1=CC(=CC=N1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2
ALogP:4.175
Target:Apoptosis related,Autophagy,Ferroptosis,FLT3,PDGFR,Raf,VEGFR
Pathway:MAPK
Information:Sorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.
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