Name:Brefeldin A
Synonyms:BFA, Cyanein, Decumbin
CAS Number:20350-15-6
Formula:C16H24O4
M.w.:280.36
DMSO (mg/mL)Max Solubility:4
DMSO (mM)Max Solubility:14.27
Form:free base
SMILES:CC1CCC/C=C/C2CC(O)CC2C(O)/C=C/C(=O)O1
ALogP:2.152
Target:Antibiotics,Apoptosis related,ATPase,Autophagy,CRISPR/Cas9,Mitophagy
Pathway:Transmembrane Transporters
Information:Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.
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